Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax
نویسندگان
چکیده
منابع مشابه
Channel Properties of Nax Expressed in Neurons
Nax is a sodium-concentration ([Na+])-sensitive Na channel with a gating threshold of ~150 mM for extracellular [Na+] ([Na+]o) in vitro. We previously reported that Nax was preferentially expressed in the glial cells of sensory circumventricular organs including the subfornical organ, and was involved in [Na+] sensing for the control of salt-intake behavior. Although Nax was also suggested to b...
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The epithelial Na(+) channel (ENaC) is an end-effector of diverse cellular signaling cascades, including those with phosphatidylinositide second messengers. Recent evidence also suggests that in some instances, phospatidylinositides can directly interact with ENaC to increase channel activity by increasing channel open probability and/or membrane localization. We review here findings relevant t...
متن کاملSPAK Sensitive Regulation of the Epithelial Na Channel ENaC.
BACKGROUND/AIMS The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS ENaC was expressed in Xenopus oocytes with or without additional expression of w...
متن کاملCorrection: Channel Properties of Nax Expressed in Neurons
Supporting Information S4 Fig. Immunohistochemical staining of rat and mouse brains with anti-Nax antibodies. Immunohistochemical staining of the coronal sections of rat and mouse brains, containing the median preoptic nucleus (MnPO) (A) and median eminence (B) with anti-rat Nax [12] and anti-mNax antibodies. Immunohistochemical staining was performed as described in S5 File. Neither rat nor mo...
متن کاملRegulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
The epithelial Na+ channel (ENaC), composed of three subunits (alpha beta gamma), plays a critical role in salt and fluid homeostasis. Abnormalities in channel opening and numbers have been linked to several genetic disorders, including cystic fibrosis, pseudohypoaldosteronism type I and Liddle syndrome. We have recently identified the ubiquitin-protein ligase Nedd4 as an interacting protein of...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2016
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2016.10.42